That earlier choice of acetate as the dialysate buffer is now (very early 80’s) becoming a problem. Oh, it was great when dialysis was slow (12 hours) and had “tight” membranes; but, now, with the more efficient membranes and shorter dialysis, the saw-tooth pattern that existed for toxins is now occurring for our blood buffer. During dialysis, the acetate replaces the bicarbonate buffer; after dialysis, the acetate is slowly converted to bicarbonate. Obviously, this is not the best situation for patients.
The Framingham health study indicates that about 1 in 5 (both men and women) persons will develop heart failure over the course of their lives. Once there is a myocardial infarction (MI, â€œheart attackâ€), current therapy employs drug therapy, but that does not treat the underlying cause(s).Â There is a loss of heart tissue that requires regeneration and repair.
Dr. Mark Ware of McGill University reported in the Journal of the Canadian Medical Association reported results (small study, 23 patients) that demonstrated reduced chronic neuropathic pain for those with damaged nerves. These patients suffered from pain caused by injuries to the nervous system from post-traumatic (e.g. traffic accidents) or post-surgical (e.g. cut nerves) events. Their pain has not been controllable via standard therapies. Four different potencies of cannabis (2.5%, 6%, and 9.4% of tetrahydrocannabinol- the active ingredient in cannabis, as well as a placebo – 0% active ingredient) were among the study parameters.
Now, we have a prepared concentrate solution, but we still have to prepare the flat plate units for each use. A few inventors have begun to improve on the design- a prepackaged flat plate unit (made of plastic and several layers of membranes so the unit is about 1 foot long and not five feet long). And instead of inserting needles into veins each time, a physician-inventor developed a surgical cannula (and improved on that design several times hence).
Imagine this scenario. Dialysis as a therapy is just starting to ‘click’. Treatments are available in one of two modalities- coil or flat plate. The coil system (shown below) reminds one of a giant washing machine, with a bathing solution of warm salt water, bubbled carbon dioxide, and a plastic device (looking like a car “air filter”) inserted inside this mess, through which passes your blood. The “air filter” is a membrane that separates the solution from your blood; the impurities from your blood are whisked away by the solution.