Bone metabolism and Energy metabolism- linked? Data says yes, but how tightly?

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Gerard Karsenty, now at Columbia (with various cohorts, the most common being Patricia Ducy, his now-wife) has spent some 15 years investigating the interactions and regulations effected by osteocalcin (controls the processes by which calcium phosphate is deposited onto bone cells). In a fairly radical theory (even to this day) Karsenty has been studying the links between osteocalcin (which affects the skeletal system (bone) and energy metabolism. Energy metabolism is a process that goes askew in diabetes.  (Our bones are involved with dynamic processes: Osteoblasts form and shape bone tissue, while osteoclasts break it down; the system is called “remodeling”.)

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