Rat poison. Yes, rat poison. Until recently it was the ONLY drug (which means something different from the drug of choice) to counter potential blood clotting in humans who undergo dialysis and/or transplantation. Other folks took the drug to avoid cardiovascular complications because they had artificial heart valves or a condition called atrial fibrillation, among other situations.
Dialysis is a compound word of dia and lysis– which means ‘through’ ‘splitting or loosening’. In chemisty, the term defines the process of separating particles within a liquid, based upon their ability to pass through a membrane. In medicine, we use the term when we remove impurities in the blood based upon their ability to pass through a membrance. Until now.
Way back when I became interested in dialysis, the buffer of choice was sodium bicarbonate. Now this compound is not exactly easily dissolved in water. But, since we were making batches of dialysate that were used for a single treatment, it didn’t matter that a concentrate couldn’t be produced.